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德國Responsif
Responsif 在癌癥疫苗應(yīng)用和傳染性疾病疫苗研發(fā)領(lǐng)域提供其獨(dú)家專有納米級(jí)輸運(yùn)技術(shù)－NanosVir? 輸運(yùn)技術(shù)。
NanosVir? 輸運(yùn)技術(shù)的兩大表現(xiàn)方式是：(i) 分別包含外殼蛋白、次要外殼蛋白VP1、VP2/VP3和用于蛋白質(zhì)包埋的鼠類多瘤病毒的蛋白質(zhì)類納米顆粒（非感染性、不能復(fù)制、無濾過性毒菌DNA 的病毒式顆粒）和(ii) 供蛋白質(zhì)/ 縮氨酸在微粒表面排列使用的單獨(dú)VP1 類納米結(jié)構(gòu)載體。
在研發(fā)應(yīng)用的基礎(chǔ)上，這些納米顆粒在酵母、大腸桿菌里以再結(jié)合方式顯現(xiàn)出來。納米微粒結(jié)構(gòu)的制造工藝可升級(jí)、轉(zhuǎn)移到環(huán)磷酸鳥苷生產(chǎn)設(shè)備。對(duì)于探索性項(xiàng)目，Responsif 可與客戶簽署付費(fèi)服務(wù)合同，根據(jù)客戶需要，為蛋白質(zhì)/ 縮氨酸/ 多抗原決定基實(shí)體提供NanosVir? 輸運(yùn)技術(shù)。
鑒于我們擁有NanosVir? 輸運(yùn)技術(shù)的知識(shí)產(chǎn)權(quán)，我們可以與用戶簽署合同，建立長(zhǎng)期業(yè)務(wù)模式（如：以專利權(quán)稅為基礎(chǔ)的模式或成立合資公司）。

With its NanosVir? delivery technology responsif offers exclusive and proprietary
nanoparticular delivery technologies for application in the field of cancer vaccines (main
activities) and in the area of vaccine development against infectious diseases.
The two main NanosVir? delivery technologies represent (i) protein-based nanoparticles
(non-infectious, non-replicating virus-like-particles w/o viral DNA) consisting of the major
and minor coat proteins VP1 and VP2/VP3, respectively, of murine polyomavirus for protein
encapsulation and (ii) solely VP1-based nanostructured carriers for protein/peptide display on
the particle surface.
Depending on the field of R&D application these nanoparticles are recombinantly expressed
in yeast or in Escherichia coli. The manufacturing process for the nanoparticulate structures
is scalable and transferable to cGMP production facilities. For exploratory projects responsif
may initially offer fee-for-service contracts for NanosVir? delivery of customer-specific
protein/peptide/multi-epitope entities. Based on our strong intellectual property position for
the NanosVir? technology such contract can be extended to long-term business models (e.g.
royalty-based models or joint-ventures).